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The most significant byproduct of this anaerobic shift is the rapid accumulation of lactic acid, leading to prolonged intramuscular acidosis

Nature (2021) 559(7886):5468

It is an important cause of travelers diarrhea, chronic abdominal pain, chronic fatigue, and failure to thrive in children

The study is based on the analysis of the main existing ancient cartographic documents

20 PDE5 inhibitors (tadalafil/sildenafil): PDE5 inhibitors possess a strong physiologic rationale for HAPE treatment due to their ability in pulmonary vasodilation