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Pen preparation Allow the pen to reach room temperature before injection, which may reduce injection discomfort

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11.1% on placebo) Headache: approximately 14% Fatigue: approximately 11% Dizziness: approximately 8% Hair thinning: approximately 3% (vs

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5-12 However, in clinical trials, including SURMOUNT-1 for tirzepatide and STEP 1 for semaglutide, participants were permitted to remain on a given dose for up to 4 additional weeks, as needed, to allow for the dissipation of any GI AEs