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The non-natural environment of cells that grow in a monolayer, while attached to an artificial matrix is a major difference between the native tissue and such cultures, together with the lack of microenvironment provided by the actual tissue architecture [87]

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Clinical trial participants experienced weight reduction of up to 12.4%

Weintraub S, Salmon D, Mercaldo N, Ferris S, Graff-Radford NR, Chui H, et al