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Obesity pharmacotherapy from the @TheAACE diabetes algorithm: GLP1/GIP and GLP1 RAs produce ~1020% weight loss with A1c reduction, while older agents like phentermine, orlistat, and naltrexone/bupropion have less efficacy and safety tradeoffs
When you're in the early-to-mid stages of clinical development for a metabolic drug, you focus on the most critical outcomes
And though B12 is the focus of this article, it isnt the only vitamin or mineral that you need to plan for if you give up animal products
Thus new therapeutics strategies are required
Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content
