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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections

[1] [3] Patients with dietary deficiency and intact absorption may require less frequent injections or may be suitable for high-dose oral supplementation instead (typically 50-150 micrograms of cyanocobalamin daily between meals)

Reconstitution and handling

Over a comparable 68-week period, trial participants saw roughly a 16% reduction in body weight a substantially larger effect than liraglutide

It cannot confirm sterility