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Wong CK, McLean BA, Baggio LL, et al

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3.1.3 Anti-fibrotic and hepatoprotective effects Fibrosis serves as a crucial of prognosis in MASLD, with progressive extracellular matrix deposition leading to cirrhosis and liver failure

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While others have reported on the significant MACE reduction with GLP-1RA therapy in the secondary prevention cohort, but not in the primary prevention setting [91], our findings extend the current notion that the beneficial impact on the individual MACE constituents, particularly MI risk reduction, may be attenuated in the higher risk secondary preventative population with established CVD, often characterized by advanced age and multimorbidity status [90]