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Lys 16 Replacing the Gly 22 of GLP-1 with Ala or Aib slightly decreased both its affinity and activity (Ala IC 50 : 0.27 nM0.57 nM;EC 50 : 2.6 nM4 nM)

Some peptide medications, most notably Zepbound, additionally stimulate GIP receptors, further augmenting fat metabolism

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This phenomenon may be associated with an increase in the number of glutamatergic neurons, as well as elevated levels of c-Fos, GLP-1 expression, and GLP-1 receptor activity in the BLA

Caution: you should never take both medications at the same time, and you shouldnt switch back and forth repeatedly