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doi:10.1186/s12967-023-03885-2

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Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, et al

[4] Some individuals report a temporary feeling of restlessness or hyperactivity, while others may feel sleepy after the injection

The PGLs of the rats in each group were estimated after 48 h, and on the 14th day and the 28th day after STZ administration ( Mechanical allodynia Von Frey filaments were used to assess the mechanical allodynia on the 14th day of treatment ( Thermal hyperalgesia After habituation, thermal hyperalgesia was evaluated by placing the hind paws of the rats on a hot-plate, adjusted to a constant temp (55 0.5C) on the 28th day for confirmation of DN ( Antioxidant assays Investigation of oxidative stress markers in the sciatic nerves and spinal cords of the rats was significant in discerning the damage caused by STZ-induced DN