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Pre-clinical studies have demonstrated mixed findings, including potential protective effects of GLP-1 RAs in the context of diabetic retinopathy, with GLP-1 receptors found in the RPE serving a neuroprotective role in conditions of high glucose

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By inhibiting NNMT activity, this compound may support improved cellular energy production and metabolic function

Glutathione levels are decreased via xCT inhibition due to the deprivation of cellular Cys, and enzymes that require GSH are disabled

Referral to certified lymphedema therapists (CLT-LANA) and specialized lymphedema clinics is appropriate for complex cases, inadequate response to initial therapy, or when surgical evaluation is warranted