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doi: 10.1007/s13311-021-01088-5

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The reclassification to Category 2 may serve as a catalyst for pharmaceutical companies and research institutions to invest in the rigorous clinical trials required for formal FDA approval

While B complex vitamins are generally considered safe, high doses can cause side effects

aeruginosa PyrC2 has lost the most N-terminal of the Zn1-coordinating His residues, which is replaced by a Gln that is conserved in other Zur-regulated PyrCs (Figure 29D)