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Brand manufacturers can file supplemental NDAs to add new approved indications, then list the associated method-of-use patents, which can run years beyond compound patent expiration

10.1074/jbc.M313236200 172 KannoT.TanakaK.YanagisawaY.YasutakeK.HadanoS.YoshiiF.et al

In South Korea , from 2009 to 2018, the prevalence of class I, II, and III obesity increased from 29.1%, 3.2%, and 0.3% to 32.5%, 5.2%, and 0.81% respectively