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In April 2025 Pfizer was forced to discontinue a clinical trial with one of its experimental GLP-1 medicines to treat obesity due to potential drug induced liver injury found in one of the participants

This GPX1 polymorphism might confer a greater susceptibility to Keshan disease in carriers with low selenium nutritional status (53)

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Specific to spinal applications, it has shown benefits in sciatic nerve repair, spinal cord injury recovery, and preliminary disc lesion models