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Heavy or frequent drinking can dramatically reduce glutathione stores, particularly in the liver, as it works overtime to detoxify the byproducts of alcohol

the American Heart Association/American Stroke Association guideline suggests GLP-1RAs as second-line to metformin regardless of baseline HbA1c in individuals with established atherosclerotic CVD to avoid further vascular events 7

Next-generation therapies are emerging, showing promise for greater weight loss and potential cardiovascular improvements, with ongoing trials evaluating long-term outcomes

Unlike endogenous GLP-1, which is rapidly degraded by dipeptidyl peptidase-4, GLP-1 receptor agonists are resistant to degradation and have longer half-lives, particularly for modern long-acting agents, such as liraglutide, dulaglutide, semaglutide and tirzepatide