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Despite the intestinal barrier being designed to limit the translocation of luminal components, certain factors disrupt its integrity including genetic predisposition, gut microbiota dysbiosis and environmental factors such as those present in food and oral therapeutics (Fig

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19.1 Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S 1999 Thymus and Autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T Cells as a key function of the thymus in maintaining immunologic self-tolerance