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Although their largest involvement is in nutrient and metabolic regulation, around 10% of them might cross the BBB, as shown in animal studies with mechanistic details (Monteiro-Cardoso et al., 2021)
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Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans
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That said, the authors emphasized the need for more research, especially on the diets long-term impact. Takeaway Long-term adherence to the keto diet, especially when coupled with significant weight loss, can lead to irregular periods or their discontinuation
