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The STEP trials demonstrated that semaglutide produces sustained weight loss of 15-22% over 68 weeks in people with overweight or obesity, while the SURMOUNT trials showed tirzepatide delivering even greater reductions of 20-22% at standard doses

Circulation 2000, 101: e3-e11

This matters because the therapeutic effect, appetite suppression, reduced caloric intake, and weight loss, comes from the semaglutide

Effects of cholecystokinin-oktapeptide (CCK-8) on food intake and gastric emptying in man

06/16/2026 National Academies Calls For Crew Radiation Tracking - From AvWeb - "A new report says the FAA has enough science and operational tools in place to begin formal oversight of airline crew exposure