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90 In this process, epithelial cells lose their characteristic structure and functions, including cell polarity, tight junctions, and intercellular adhesion, and gain the morphology and functions of mesenchymal cells, including cell migration, invasion, and resistance to apoptosis

(2013) 74:e1229

Why Strength Training Matters During Weight Loss Scientific American explains that during weight loss, the body draws energy not only from stored fat but also from lean tissue, including muscle. This means that without a stimulus to maintain muscle, some degree of muscle loss is expected

doi:10.1001/jamanetworkopen.2026.9917

Researchers have found that hypoxia is an essential positive trigger for ferroptosis, and HIF-2 enhances lipid peroxidation while the depletion of HIF-1 decreases sensitivity to ferroptosis (Zou et al., 2019)