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Whether the additional glucagon receptor activity in retatrutide meaningfully alters the gastrointestinal side-effect profile compared with single or dual agonists has not been established in head-to-head studies, and such comparisons should be interpreted with caution
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We previously found that fusion of a peptide or a single-chain variable fragment to the C-terminal end of albumin reduced FcRn binding up to 2-fold, and to a greater extent than when fused to the N-terminal end 12