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Appendix 1 Author Relationships With Industry and Other Entities (Relevant) 2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk Appendix 2 Peer Reviewer Relationships With Industry and Other Entities (Comprehensive)2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk Appendix 3 Abbreviations ACC = American College of Cardiology ACS = acute coronary syndromes AHA = American Heart Association ANGPTL3 = angiopoietin-like protein 3 ASCVD = atherosclerotic cardiovascular disease AU = Agatston units BAS = bile acid sequestrant CAC = coronary artery calcium CKD = chronic kidney disease ECDP = Expert Consensus Decision Pathway FDA = Food and Drug Administration FH = familial hypercholesterolemia HDL-C = high-density lipoprotein cholesterol HeFH = heterozygous familial hypercholesterolemia HoFH = homozygous familial hypercholesterolemia LDL = low-density lipoprotein LDL-C = low-density lipoprotein cholesterol Lp(a) = lipoprotein a mAb = monoclonal antibody MI = myocardial infarction PCSK9 = proprotein convertase subtilisin/kexin type 9 PAD = peripheral artery disease PCE = Pooled Cohort Equation RCT = randomized controlled trial RD/RDN = registered dietitian/registered dietitian nutritionist RWI = relationships with industry SASE = statin-associated side effect Information & Authors Information Published In JACC Volume 80 Number 14 4 October 2022 Pages: 1366 - 1418 Copyright Copyright 2022, American College of Cardiology Foundation

It typically results from inadequate insulin secretion because of dysfunction of the insulin-secreting pancreatic beta cells

Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature

This leads to impaired ubiquitination of NRF2, an increase of NRF2 protein levels [157], and a reduction of KEAP1 levels able to sequester de novo synthesized NRF2 [159]

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