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Moreover, GLP-1R antagonism partly reduced plasma TGs and this effect could be explained by the GLP-1R-mediated insulin secretagogue effect of G49 that likely accounts for insulin-mediated de novo lipogenesis rather than a direct effect of G49 actions in the liver through the GLP-1R which is nearly absent as reported 54

Regarding the primary endpoint, all doses of tirzepatide were superior in comparison to semaglutide

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Moreover, -arrestin mediates receptor internalization and reduces the amount of receptors on the surface of the membrane