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The role of inflammatory cytokines on the aetiopathogenesis of depression

Its also important to be aware of potential interactions it may have with other supplements and drugs including aspirin and caffeine as it can increase the risk of side-effects such as bleeding

Based on several human RCTs, melatonin is considered an effective intervention to resolve delirium, ameliorate respiratory stress (i.e., ARDS), and restore circadian balance in COVID and PASC patients 664,665,666

That may be the case for the demand for an essential medicine if it is a medical necessity to patients and no good therapeutic substitute exists

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