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10.1186/s13046-019-1459-6 28 LippmanS

A study showed that vitamin D supplemented for 12 weeks in women with PCOS yielded significant results in reducing insulin concentration and HOMA-IR at fasting, 1 hour, 2 hours, and 3 hours after the OGTT 7

The heightened absorbability allows the effects of this Master Antioxidant to be maximized

This means that higher doses may be needed

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin