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A prominent example of OIS is the H-Ras G12V mutation, which triggers senescence by inducing the DDR mediated by ROS 17

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Animal and cell research points to several overlapping pathways: VEGFR2 upregulation: BPC-157 has been shown in rat tendon fibroblast studies to upregulate VEGFR2 (vascular endothelial growth factor receptor 2) expression, promoting angiogenesis

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