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Most evidence is still early-stage or preclinical

The percentage of patients diagnosed with thyroid cancer was 0.23% in the DPP4i group, 0.17% in the GLP-1RA group, 0.17% in the SGLT2i group, and 0.20% in the SU group

Modern formulations including semaglutide use synthetic compounds, need only once-weekly injections or oral dosing, and have been engineered for better stability and patient convenience without sacrificing efficacy