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LPS binds to Toll-like receptor 4 (TLR4) on the surface of Kupffer cells, activating both the MyD88-dependent pathway, which mediates NF-B signaling, and the MyD88-independent pathway involving interferon regulatory factor 3 (IRF3), ultimately upregulating TNF- transcription [49, 50]

The carnitine and acylcarnitine traffic could not occur without the concerted activity of dedicated membrane transporters localized at the cell surface and in intracellular organelles