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Furin-mediated priming of viral S protein at S1/S2 (P R RA R 685 ) [the underlined AAs refer to critical residues needed for the furin recognition] is a key determinant in the pathogenesis of COVID-19 55,73,329

which first documented that MOTS-c increases cellular NAD+ levels and activates AMPK through SIRT1, MOTS-c also increases cellular NAD+ levels as part of its activation of AMPK through SIRT1