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Viral or microbial DNA facilitates gp78 interaction with INSIG-1 and stimulator of interferon genes (STING), resulting in K27-linked polyubiquitination of STING, a noncanonical ubiquitin chain topology of ubiquitin that serves as an anchoring platform to recruit TANK-binding kinase 1 (TBK1) and facilitate its translocation to perinuclear microsomes, resulting in the innate immune response

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PMID: 6877358

Thus, maintaining zinc homeostasis requires a complex intracellular collaboration of these functional proteins

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