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We think GLP-1s may shut down the ability for stem cells in dermal white adipose tissue, a thin layer of fat beneath the skin, to signal fibroblasts to produce collagen and elastin, says Steven Dayan, MD, a plastic surgeon in Chicago who has co-authored research papers on GLP-1s aesthetic side effects

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Pill Oral Wegovy became the first FDA-approved GLP-1 pill specifically developed for weight loss, launching in January 2026

The same product can also be presented as a skin repair serum designed to support the skins recovery from environmental stress, dehydration, or over-exfoliation