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In clinical trials, participants lost an average of 15% of their body weight over 68 weeks, significantly higher than the control group

Winzeler B et al (2020) Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers

These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i

ALL patients on GLP-1s treat as having a potentially full stomach regardless of fasting duration use Rapid Sequence Induction (RSI) for general anaesthesia

If nausea, vomiting, or other side effects emerge at a higher dose, your PlexusDx provider can pause your escalation and maintain your current dose, reduce to a previous dose level, or switch to a complementary compound like semaglutide or GLP-Squared