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Although other therapeutic agents, such as colivelin, have been shown to restore the glycocalyx and reduce the plasma concentration of syndecan-1 in sepsis (127), it is not clear whether these agents are directly integrated into the glycocalyx from the circulation or whether the glycocalyx is restored by de novo synthesis by endothelial cells

Furthermore, in a series of different injurious models, acute and chronic, 1 - 13 BPC 157 consistently promotes healing after severe injuries in various tissues which are spontaneously unable to heal

This indicates that fullerenols may exacerbate cytotoxicity by inhibiting ER expression

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Should fibrosis remain partially unresolved, alternative strategies could enhance the anti-fibrotic effects of GHK