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The clinical significance is still being characterized in humans, but functional MRI data from small Phase I work show altered reward-circuit responses to food cues after tirzepatide exposure that differ from those seen with GLP-1 monotherapy [10]

Supplementing with vitamin B6 can help boost progesterone to balance excess estrogen

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3 GLP-1RAs and NAFLD/NASH When dietary nutrients are ingested, endogenous incretins (GIP and GLP-1) activate K and L cells in the gut, which then secrete GIP and GLP-1

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