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Increasing faster than every four weeks significantly raises the risk of severe nausea and vomiting

doi:10.1016/j.ebiom.2025.105612 Blagosklonny MV

The most common side effects reported were: Nausea Diarrhea Vomiting Abdominal pain Decreased appetite Indigestion Fatigue Upset stomach Constipation Dry mouth or dehydration Lightheadedness Injectionsite reactions (rash, redness) Rare but serious adverse effects include: Severe allergic reactions Increased risk of medullary thyroid carcinoma (MTC) and MEN 2 Pancreatitis Diabetic retinopathy complications Severe hypoglycemia, especially with insulin or sulfonylureas Kidney problems Gallbladder disease and gallstones This is not a complete list

The results of the low activity of FH determine the increased level of fumarate supporting cancer spread through metabolic reprograming, post-translational modifications (succination), DNA fragmentation and hypermethylation, increase of ROS levels and EMT (Fig

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