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The development of drug resistance in cancerous cells is a major cause of concern, as it not only leads to tumor recurrence but also perpetuates the cancer, resulting in poor patient survival

prolonged overactivation may promote oncogenic pathways or, as seen in clinical trials with bardoxolone methyl, adverse renal outcomes (Pergola et al., 2021)

5.5% vs 1.2%) [22], with nausea (4.3%), anxiety (2.7%), and dizziness (2.3%) being the most prevalent AEs with IPX203

Compared to cytosolic NADK (cNADK), mitochondrial NADK (mNADK) has a distinctive feature that it can directly phosphorylate nicotinamide adenine dinucleotide (NADH) to generate NADPH to alleviate oxidative stress in mitochondria

Published 2017 Sep 29