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In summary, this study showed that although most circulating IGF-1 is derived from hepatocytes, it is not the main IGF-1 that is required for postnatal growth and development (303)

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The expression of gonadotropin receptor might be regulated by IGF signaling

This functional polarity is finely modulated by membrane-bound proteins, receptors, channels, and transporters that govern essential processes such as ion homeostasis, neurotransmitter clearance, and neuroimmune signaling (Figure 4)