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In addition, the levels of two hypoxia markers, hypoxia-inducing factor 1 alpha (HIF-1) and carbonic anhydrase IX (CAIX), were significantly lower than those in the control group, indicating a reduction in hypoxia in the tumor tissues [196]

Taking the supplement on an empty stomach, or with a very light, low-protein snack, ensures that the bromelain is absorbed systemically, where it can exert its maximum therapeutic effect on tissue inflammation and microcirculation

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