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However, similar to GLP-1RAs, these agents may induce gastrointestinal adverse effects including anorexia and gastrointestinal discomfort

To further investigate the mechanism underlying the binding ability of cPLT, collagen-coated plates were pre-incubated with free anti-GPVI antibody for 30 min to block the collagen binding sites

If additional glycaemic control is needed, the dose may be increased to 1 mg weekly after at least four weeks, with a maximum dose of 2 mg weekly available for some patients