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No clinical trial has tested this specific scenario
10 As shown in FIGURE 3 , exenatide normalizes blood glucose levels by reducing fasting and postprandial glucose concentrations through a variety of mechanisms, including enhanced glucose-dependent insulin secretion, regulation of glucagon secretion, delayed gastric emptying, and decreased food intake due to centrally mediated effects on satiety
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Critically, GIP receptor activation in adipose (fat) tissue appears to enhance fat mobilization and energy expenditure beyond what GLP-1 can do alone which helps explain tirzepatides superior weight loss outcomes in clinical trials
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