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Key points Vascular damage in chronic kidney disease (CKD) increases the risk of stroke and cognitive impairment, with faster CKD progression linked to cerebral damage, subcortical infarcts and bloodbrain barrier disruption

This may be due to the bodys adjustment to increased cellular activity and regeneration triggered by GHK-Cu

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Additionally, oxidative stress affects testicular somatic cells and the hypothalamic-pituitary-gonadal (HPG) axis, contributing to lower testosterone levels and diminished spermatogenic output

This finding shed light on the shared pathogenesis of ocular and cardiovascular diseases and provided hope for broader clinical application of GLP-1RAs besides its initial glucose-lowering ability