People Taking Orforglipron Saw Substantial Reductions in Weight and A1C Levels In a 40-week placebo-controlled trial, people with type 2 diabetes taking the highest dose of orforglipron lost 16 pounds on average, or about 7.9 percent of their body weight, and were still losing weight when the study ended
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[1] [3] This incretin hormone plays a crucial role in regulating blood glucose levels, appetite, and energy metabolism
The beneficial effects observed in those patients with early onset, low atherosclerotic burden include an improvement in plaque stability score in the brachiocephalic artery, attenuation of lipid deposits in the aorta, and reduction of weight gain