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[44] [45] There is a tremendous diversity of individual P-450 gene products, and this heterogeneity allows the liver to perform oxidation on a vast array of chemicals (including most drugs) in phase 1

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Promising results have been achieved in their implementation in non-alcoholic fatty liver disease and neurodegenerative disorders, as well as in alcohol dependency therapy (31, 32)

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Extracellular flux (XF) analysis Seahorse XF analyzer (Seahorse Bioscience, Billerica, MA) was employed to simultaneously measure the flux of oxygen (oxygen consumption rate) and protons (extracellular acidification rate) of adherent cells in a microplate over time

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