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PMID: 160 Duarte-SilvaEMeuthSGPeixotoCA

GLP-1 seems to have a secondary function as a satiety signala ping to the brain to stop eating

Storage and Travel: Practical Considerations Injectable GLP-1 medications typically require refrigeration at 36-46 (2-8) when not in use, though many pens can sit at room temperature for a limited window once opened

It is therefore clear that currently available GLP-1RAs, mimicking on the peripheral action of GLP-1 (7-36) NH2 , not only ignore the yet unknown physiology of GLP-1 (9-36) NH2 or its metabolites, but they also fail to address the tissue specific physiology of GLP-1 (7-36) NH2 , while pushing to supra-physiological limits the endocrine GLP-1 receptor axis, likely explaining the reported side-effects and only partial success in the treatment of T2D

Clinical pharmacokinetics of clomipramine