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Each additional receptor target introduces new metabolic pathways into the compound's mechanism of action

The augmentation of mitochondrial functionality, alterations in intracellular GSH concentrations, and elevation of c-glutamyl transpeptidase activity collectively facilitated the physiological amplification of androgens, leading to the potentiation of OS in LNCaP human prostate cancer cells that are responsive to androgens (81)

Injectable administration bypasses this variability and may provide more consistent availability

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