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Kong X, Hu W, Cui Y, Gao J, Yao X, Ren J, et al

Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately three times the maximum recommended human daily dose based on body surface area comparisons

[1] [7] Additionally, because glucagon promotes glycogenolysis and gluconeogenesis, there is a theoretical concern regarding glucose management in people with type 2 diabetes, although the GLP-1 and GIP components appear to counterbalance this effect in practice

On the other hand, saying, "Nausea rated 7/10 happens regularly 36-48 hours after injection , goes along with doses over 1.0mg , and gets better with ginger tea " gives the doctor specific information to work with

Its also important to take your other medications according to your doctors recommendations to help prevent further damage to your kidneys.