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The GI epithelium produces IL-25 and recent studies confirm that doublecortin-like kinase 1 (Dclk1)-expressing tuft cells are the sole epithelial source (88)

10.1038/s41420-021-00610-0 92 LiX.HuJ.ZangX.XingJ.MoX.HeiZ.et al (2023b)

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Among various types of human cancer, Ewing sarcoma is a promising indication for IGF-IR-targeted therapy, since some Ewing sarcomas are highly sensitive to IGF-IR inhibition