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This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]

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Conflict of interest The authors declare that they have no known competing financial or non-financial interests that could have appeared to influence the work reported in this paper

The days immediately following your first retatrutide injection are an important period of adjustment