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It is found in the cytosol, endoplasmic reticulum, vacuoles, mitochondria, chloroplasts, peroxisomes, and the apoplast (Noctor and Foyer 1998)

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Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes

Both candidates are designed to move beyond single-pathway GLP-1 therapy, but they take very different routes: CagriSema combines an amylin analog with semaglutide, while Retatrutide compresses GIP, GLP-1, and glucagon agonism into one investigational peptide

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