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Nature (1977) 266(5597):602

J Intern Med 2004

[5] Defecation The defecation process consist of three important stages including: [6] Filling of the rectum Sensation of rectum fullness Relaxation of pelvic floor muscles in a coordinated fashion Anal sphincters and puborectalis muscle are anatomical contributors of normal fecal consistency

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Glycine Safety Glycine is typically a very safe amino acid but I should also let you know that it is possible to overdose with glycine and even natural products have cautions, medical interactions (such as clozapine), and contraindications (like anuria)