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CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation

10.1016/j.arcmed.2008.06.005 [DOI] [PubMed] [Google Scholar] 34.Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, et al

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Fulminant and late onset hepatic failure

Gonzalez's Background and Journey - Educated at prominent institutions, including Brown University and Cornell Medical College