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This localized depletion of the brain's master antioxidant is accompanied by abnormally high levels of ventricular lactate and free radicals, indicating that the brain is suffering from severe oxidative stress and impaired cellular energy metabolism

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The most commonly reported effects are mild and transient: slight redness at the injection site, occasional mild fatigue in the first few days of a protocol reflecting the circadian recalibration effect, and in some patients a temporary increase in dream vividness associated with improved REM architecture