Semaglutide and liraglutide are structurally similar molecules with high selectivity for the GLP-1 receptor, though there are some pharmacologic differences between the two notably, liraglutide has a higher steady state concentration and greater receptor binding affinity than semaglutide, while semaglutide has an increased affinity for serum albumin (thereby improving resistance to degradation) and a longer half-life than liraglutide [38, 61, 62]
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but with the understanding that the potential development of antibodies against the medication may pose a threat to utilizing it in the future for active weight loss goals
Thus, the authors claim that enhanced DPP4 expression in NAFLD liver may rather be associated with IR than triglyceride accumulation and may promote the progression of liver disease via subsequent deteriorations in glucose metabolism
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